Integrating Proteasome Plus Second-Generation IMiD-Based Regimens into Relapsed/Refractory Multiple Myeloma Management

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Release Date: May 31, 2016
Expiration Date: May 31, 2017

Expected time to complete this activity as designed: 30 minutes
There are no fees for participating in or receiving credit for this online activity.

Program Overview

The treatment of patients with relapsed/refractory multiple myeloma includes multiple therapeutic options, including proteasome inhibitors (PIs) and immunomodulatory drugs (IMiDs), providing a variety of synergistic drug combinations and possible regimen sequences when prior treatment becomes ineffective. Given the availability of the second-generation PI carfilzomib, practitioners are challenged with understanding how to appropriately integrate bortezomib- and carfilzomib-containing two- and three-drug regimens into clinical practice, while individualizing treatment and managing adverse events. Join Dr. Antonio Palumbo, Associate Professor of Clinical Hematology and Director of the Myeloma Unit at the University of Torino, as he reviews the latest data on utilizing PI-containing regimens and explains current strategies for devising treatment plans for patients with relapsed/refractory multiple myeloma.

Target Audience

This activity is designed for physicians, pharmacists, physician assistants, and other health care professionals who have an interest in enhancing their clinical skills in multiple myeloma.

Learning Objectives

Upon completion of this educational activity, participants should be able to:

  • Recall dose schedules for triple-agent regimens comprising either of the two available proteasome inhibitors in combination with second-generation IMiD and dexamethasone
  • Compare and contrast which patients may benefit from the KRd or VRd regimens in the relapsed/refractory disease setting
  • Identify efficacy and safety signatures for discussed regimens and mitigation strategies which may reduce the frequency or severity of their occurrence


Integrating Proteasome Plus Second-Generation IMiD-Based Regimens into Relapsed/Refractory Multiple Myeloma Management – Antonio Palumbo, MD

Instructions for Participation and Credit

This activity is eligible for credit through May 31, 2017. After this date, this activity will expire and no further credit will be awarded.

  1. Read the target audience, learning objectives, and faculty disclosures.
  2. You may be asked to complete a short pre-test before accessing the educational content. This must be completed in order to move forward in the activity.
  3. Complete the educational content as designed.
  4. Complete the post-test. To receive a certificate, you must receive a passing score of 70%.
  5. Complete the activity evaluation survey to provide feedback and information useful for future programming.
  6. Certificates for CME credit may be printed immediately after successfully completing the post-test and activity evaluation. Pharmacist credit will be uploaded to CPE Monitor 4 weeks following receipt of a completed, qualified form.

Faculty Biography

Antonio Palumbo, MD
Associate Professor of Clinical Hematology
Director, Myeloma Program
Department of Oncology
University of Torino
Torino, Italy

Dr. Antonio Palumbo received his medical degree from the University of Torino, Italy, where he served his residency in internal medicine and held a fellowship in hematology/oncology. He is an Associate Professor of Clinical Hematology, and Director of the Myeloma Program, Department of Oncology at University of Torino. He is also a visiting physician at University of Texas MD Anderson Cancer Center in Houston.

In addition to membership in numerous professional organizations, including the Italian Society of Hematology (SIE), Italian Society of Experimental Hematology (SIES), European Society of Medical Oncology (ESMO), European Society of Hematology (EHA), American Society of Hematology (ASH) and the American Society of Clinical Oncology (ASCO), Dr. Palumbo is on the Board of Directors of the International Myeloma Society. He has authored more than 400 publications in peer-reviewed journals as well numerous abstracts and several textbook chapters. Dr. Palumbo specializes in malignant hematology and medical oncology and has clinical and research interest in plasma cell dyscrasia, his current research focuses on the pathogenesis and treatment of multiple myeloma.


Accreditation Statement: MediCom Worldwide, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Designation Statement: MediCom Worldwide, Inc. designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
MediCom Worldwide, Inc. is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This activity is acceptable for 0.50 contact hours of Continuing Education Credit. Universal Activity Number: 827-0000-16-089-H01-P. Knowledge-based CPE activity.

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Faculty Disclosure

Dr. Antonio Palumbo has received honoraria related to speakers’ bureau activities from Bristol-Myers Squibb Company. He has received grant support related to research activities as well as honoraria as a consultant from Amgen Inc., Bristol-Myers Squibb, Celgene Corporation, Genmab A/S, Janssen-Cilag Ltd., Merck & Co., Inc., Novartis AG, sanofi-aventis U.S. LLC, and Takeda Oncology.

Planning Committee Disclosures

The individuals listed below from MediCom Worldwide, Inc. reported the following for this activity: Joan Meyer, RN, MHA, Executive Director, and Patrick Brooks, PharmD, Medical Director, Oncology have no relevant financial relationships.

Peer Reviewer Disclosure

In accordance with MediCom Worldwide, Inc. policy, all content is independently peer reviewed for balance, objectivity and commercial bias. The peer reviewers have no relevant financial relationships to disclose.

Off-Label Disclosures/Investigational Disclosures

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The opinions expressed in the educational activity are those of the faculty. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. Further, attendees/participants should appraise the information presented critically and are encouraged to consult appropriate resources for any product or device mentioned in this program.

Dr. Palumbo has indicated that he does intend to discuss off-label uses of drugs, mechanical devices, biologics or diagnostics approved by the US Food and Drug Administration (FDA) for use in the US.

Dr. Palumbo has indicated that he does intend to discuss investigational drugs, mechanical devices, biologics or diagnostics not approved by the FDA for use in the US.

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Provided by MediCom Worldwide, Inc.
This activity is supported by an educational grant from Amgen Inc.

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