In recent years, important new advances have been reported in the frontline treatment of newly diagnosed multiple myeloma (NDMM) patients. Despite this progress, however, significant challenges remain. In this activity, two myeloma experts will discuss the most recent information and evidence regarding frontline therapy including selecting regimens based on individual patient disease factors, treatment regimens for transplant-ineligible and transplant-eligible patients, and key practice considerations for NDMM.