That's a very good question. I think if someone has previously been on IV Dara, it's a good idea to go back and see if they had an infusion-related reaction. If they had a reaction, was it just mild (Grade 1-2) or not? If they had no reaction to the IV formulation and they're getting SQ formulation, it's okay to watch those patients for maybe an hour before letting them go home. I think we've experienced this in our clinical practices and see this quite frequently.

For someone who did have a higher grade infusion-related reaction with IV formulation, even though the product is the same, I think the first time patients are getting it, it may be worthwhile keeping that patient around a little bit longer, but no longer than four hours.